A 100% CURE FOR PEYRONIES.....IN 2020  


The possibility of a complete cure for our condition has progressed from
the realm of science fiction to a real probability, but human treatment in
this field is still about a decade away.  The field of Regenerative Medicine
shows the most promise and there are many exciting experiments being
The most promising and the one that is directly related to penile
regeneration was conducted on rabbits at the
Wake Forest University
Baptist Medical Center’s Institute for Regenerative Medicine.  

Previously, reconstructing damaged or diseased penile erectile tissue has
been a challenge to repair because of the tissue’s unique structure and
complex function. Prior to the Wake Forest’s experiment, no tissue
replacement therapy or treatment had been available that would allow for
the return of completely normal penile functioning.  As was reported in the
online edition (Nov 9-13, 2009) of the Proceedings of the National
Academy of Sciences, the researchers first harvested smooth muscle
tissue and other cells from laboratory rabbit tissue. These cells were
allowed to multiply in the laboratory and then injected into a
three-dimensional scaffold that provided support while the cells
developed.  As early as one month after implanting the material in the  
penis, organized tissue with vessel structures began to appear.   
Testing showed that the new tissue was functioning in a completely
normal manner. Vessel pressure within the erect tissue, response to
chemical changes and vein draining of blood after an erection were all
normal.  Their ejaculate contained sperm in 2/3 of the cases and 25% of
the females with whom these rabbits mated with become pregnant.  The
tissue engineered in this experiment is known as the corpora cavernosa of
the penis (Note: The same tissue affected by PD). The lead researcher
expressed hope that men with a number of conditions, i.e., traumatic injury
of the penis, congenital defects, etc. would ultimately benefit from this
treatment.  Of course, testing on humans is a number of years away.  
(I gave a donation to this medical facility with a note about my PD and
suggested their approach appeared to be a promising treatment for my
condition. You may want to do the same).

As noted in the above article,  a “scaffold” was required in order for the
material to bond, grow and organize.  This scaffold is a first generation
approach to this crucial step in the regenerative process.  However, this
process may take a giant leap forward with the arrival of the first
commercial 3D bio-printer for the manufacturing of human tissue and
organs.  This new machine, which costs about $200,000, has been
developed by
Organovo, a San Diego company that specializes in
regenerative medicine.  This machine works in a similar fashion to ink-jet
printers, but takes it a step further than the previously mentioned scaffold
approach by depositing droplets of polymer with the cellular material
which then fuses together to form a structure. This eliminates the need to
construct a scaffold.  To start with, only simple tissues, such as skin,
muscle and short stretches of blood vessels will be made. The first
production models of these machines will soon be delivered to research
labs.  This ink-jet approach is apparently becoming more common and  
being used for a number of impairments.  MSNBC reported a rigged
device inspired by common ink-jet printers has been used in experiments
on mice.  Skin cells were sprayed directly onto burn victims via the ink-jet
printer method, quickly healing their wounds as an alternative to skin
grafts.  Another company,
Invetech, has developed a laser based
calibration system to ensure that the print heads from machines such as
the 3D bio-printer, deposit their material accurately along with a
computer-graphics system which allows cross-sections of tissues and
body parts to be designed.    

In a related development, the American Armed Forces Press Service has
reported on their “translational research activities.”  Which is defined as
putting research into practice.  They are also employing the “scaffolding”
method to get tissue to grow in order to replace a missing or damaged
body part.  One area targeted for research is to develop an effective
approach to eliminate scarring as during wound healing process. (Of
course, this is the process by which PD develops).  The military has a five
year, $250 million budget for this research.