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MORE ON PROSTATE CANCER AND PEYRONIES
This website's primary focus is Peyronies Disease (PD).
A few months ago I started to write about emerging
medical research that revealed that prostate cancer
treatment, particularly radical prostatectomies,
significantly increased the incidence of PD. More
disturbing is that many physicians and virtually all their
patients were and still are unaware of this connection.
Little did I know that this topic would become the most
read about one on the website. If you are new to this site
and want to review past articles click the links below:
There is a new book on prostate cancer treatment that I
recommend, Invasion of the Prostate Snatchers by Mark
Scholz, M.D. a respected prostate oncologist and Ralph
Blum, a man with prostate cancer. The authors claim that
80% of prostate cancer surgeries are not necessary and
that the adverse effects of treatment outweigh any
possible benefits. These cancers are very slow growing
and the patient will most likely die of another cause. The
authors do a thorough job of discussing the available
treatments and probable side effects, including
incontinence, impotence and erectile dysfunction.
Guess which treatment side effecte was not ever
mentioned in this book. Our conditon, PD. I did write
Dr. Scholz and he responded asking for citations which I
provided. Hopefully, any updated version of this book
will mention the increased incidence of PD associated
with prostate cancer treatment.
Active Surveillance and Quality-Adjusted Life Expectancy
(QALE). These terms are going to become more common
as a result of an important and widely quoted study that
appeared in the December 01, 2010, Journal of the
American Medical Association. In reviewing the data on
prostate cancer mortality, it was noted that 48 additional
men would have to be treated for prostate cancer to
prevent 1 cancer death. Essentially, the researchers
performed a statistical analysis of the benefits vs. adverse
events associated with treatment and concluded that for
older men active surveillance is a reasonable decision.
Again, in going into detailed statistical data on adverse
events associated with treatment, not once was PD
mentioned. I wrote the author, but she did not respond.
The ignorance about this link is common throughout the
medical profession and makes it impossible for any man
considering treatment to make an informed decision.
Past articles have discussed in detail the increased
incidence of PD and prostate cancer surgery. What about
other treatments such as radiation and HIFU?
I received the following email:
I was diagnosed with Prostate Cancer in April of 2004. I
had 34 External Beam Radiaton Treatments. After the
treatments my gland reduced in size, and my discharge
became clear as water. My PSA never fell below 2.66,
then began to rise rapidly. I began Hormone Deprivation
Therapy in February 2008. The side effects were
distressing. About five months ago I discovered two
depressions of the right side of my penis. It no longer
pointed straigh ahead, but leaned to the right. I
experienced some discomfort during intercourse, and did
use Viagra to help me with some degree of Erectile
Dysfunction. My Urologist has examined me, and feels
that I do have a mild case of Peyronies. I understand that
it may heal on its own. Prior to developing the two
depressions in my penis, I measured about 6 1/2 inches in
length. Now, I barely measure 5 inches. This has brought
me great distress, and my penis slightly arcs downward,
which makes penetration into my wife's vagina a little d!
ifficult. I would really like to know if the radiation could
have caused this, or if the hormone deprivation may have
been the cause. And, if it may cure on its own, and if my
penis will ever recover to its original length
This man's condition maybe more than just a coincidence.
An article appeared in the Journal of Urology, 2003 July,
titled Radiation Increases Fibrogenic Cytokine Expression
by Peyronie's Disease Fibroblasts.
Four PD plaque derived cultures were irradiated. The
data suggested that radiation may in fact increase the
production of fibrogenic (scar tissue) cytokines which
may promote the process involved in Peyronies Disease.
Another treatment is High Intensity Focused Ultrasound
H.I.F.U. I received a email from another man who
underwent this treatment and apparently also developed
PD.
Desperate men around the world are being 'duped' into
paying ten's of thousands of dollars for H.I.F.U. Many
think High Intensity Focused Ultrasound is the "miracle"
cure for prostate cancer,with very little risk .However, no
one ever discusses the risk of peyronies.