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NEWS IN BRIEF
LISTEN TO DR. TOM LIU
LISTEN TO DR. TOM LIU
Dr. Liu is a Peyronie's Disease Specialist. In this interview, he
makes a number of critical points necessary to understand the
disease and how Xiaflex may or may not help to alleviate the
symptoms. Most physicians will inform patients that PD is a
disease whereby men develop scar tissue or plaque in the penis
resulting in curvature during erection. At best, this is incomplete
and somewhat inaccurate. Dr. Liu is correct in stating that PD is
primarily a disease whereby the penis has a elastin disorder.
Consequently, the injection of Xiaflex into the plaque may need to
be followed by additional stretching or traction in order to result in
symptom relieve. In a previous edition of this site, I have written
extensively about this issue and it is absolutely critical for men
looking to regain a satisfactory sex life after PD to understand
this. Click on the link below to be taken to the "elasticity" issue of
www.curepeyronies.net.
makes a number of critical points necessary to understand the
disease and how Xiaflex may or may not help to alleviate the
symptoms. Most physicians will inform patients that PD is a
disease whereby men develop scar tissue or plaque in the penis
resulting in curvature during erection. At best, this is incomplete
and somewhat inaccurate. Dr. Liu is correct in stating that PD is
primarily a disease whereby the penis has a elastin disorder.
Consequently, the injection of Xiaflex into the plaque may need to
be followed by additional stretching or traction in order to result in
symptom relieve. In a previous edition of this site, I have written
extensively about this issue and it is absolutely critical for men
looking to regain a satisfactory sex life after PD to understand
this. Click on the link below to be taken to the "elasticity" issue of
www.curepeyronies.net.
Xiaflex trials
As you probably know, the Xiaflex trials are continuing and we
are all waiting to see if the final results will result in FDA approval
sometime in mid- 2011. In their public relations material, the
manufacturer, Auxillium, reported that side effects were very
minor and short term. Most were limited to bruising, edema or
pain. No significant or long terms adverse events attributable to
the drug were reported. Is this a way of saying there are
significant adverse events, but the company is stating that it is due
to problems with the administration of the drug?
Given that at least 1200 doses of Xiaflex were given by the end of
phase II of the trial, I am a little skeptical that so many injections
in the penis only resulted in such minor adverse events.
According to the WSJ, December 12, 2008, the director of the
National Library of Medicine's clinical trial section commented on
clinical trials in general that.. “there is data that you are not
seeing.” The New England Journal of Medicine, October 29, 2009
and 3/10/2010 have noted their is weakness of reporting of clinical
trial data. Whether Xiaflex injections are so extremely safe, I
guess we will just have to wait for further information.
For a more in depth discussion of clinical trials, I would
recommend the book, White Coat, Black Hat.
As you probably know, the Xiaflex trials are continuing and we
are all waiting to see if the final results will result in FDA approval
sometime in mid- 2011. In their public relations material, the
manufacturer, Auxillium, reported that side effects were very
minor and short term. Most were limited to bruising, edema or
pain. No significant or long terms adverse events attributable to
the drug were reported. Is this a way of saying there are
significant adverse events, but the company is stating that it is due
to problems with the administration of the drug?
Given that at least 1200 doses of Xiaflex were given by the end of
phase II of the trial, I am a little skeptical that so many injections
in the penis only resulted in such minor adverse events.
According to the WSJ, December 12, 2008, the director of the
National Library of Medicine's clinical trial section commented on
clinical trials in general that.. “there is data that you are not
seeing.” The New England Journal of Medicine, October 29, 2009
and 3/10/2010 have noted their is weakness of reporting of clinical
trial data. Whether Xiaflex injections are so extremely safe, I
guess we will just have to wait for further information.
For a more in depth discussion of clinical trials, I would
recommend the book, White Coat, Black Hat.
