One of the great aspects of science is that through intuition or serendipity someone will find a correlation between two seemingly unrelated facts which may turn out to have some significance. When men develop PD they usually experience a decrease in elasticity of the spongy tissue of their penis and this is one reason why they experience a decrease in penile length and girth. An Israeli professor of plant physiology who was interested in the problem of plant plasticity hypothesized that plants and male erectile dysfunction problems were similar and came up with the idea of adding an ED drug to flowers to determine if this would keep them fresh and firm. Yes, these drugs do keep plants fresher as compared to plain water. The staff at the eDrugstore Science staff decided to test all the ED drugs and after 7 days Levitra was the clear winner.
Losartan - In a previous edition, I also pointed out that Losartan has demonstrated antrifibrotic properties as relates to penile recovery after a RP. I also suggested that men with early stage PD talk to their urologists about taking this inexpensive, safe medication in the hopes that it would lessen the progression of PD. Apparently there is a great deal of interest in the use of Losartan as a systemic anitfibrotic treatment for a variety of conditions. Click here for a current clinical trial with this medication on a fibrotic condition.
PD is a fibrotic disorder in which cells can’t regenerate and are replaced by scar tissue. There are many human disorders with these characteristics. Hopefully, someone working in another field may come up with an effective treatment that can help with our condition. As in many events in science and life, serendipity plays an important role. Here is one example. A scientist at the Wistar institute in Philadelphia was study lupus in mice. To distinguish one mouse from the other, she poked small holes in their ears. She observed that these small holes kept closing. And there was no scar, the tissue was perfect. She wondered if there was a mechanism at play that could be used to treat injuries. The researcher found that these cells did not express a single gene, P21, and she is now working on how to suppress this gene in order to generate injuring healing without any scarring. (Scientific American March 23, 2010.)
FDA Panel Recommends Approval of Drug For Lung Scarring An FDA panel voted 9-3 in favor of approving, Pirfenidone, which was developed to treat an incurable and often fatal lung condition known as idiopathic pulmonary fibrosis. The developing company conducted two studies to determine if their drug improved a measure of lung function. One of the two studies did meet the goal. (Wall Street Journal 03/10/10). Of course, the hope is that some time in the near future it can be determined if this medication can be used for our condition.
PD is a disease that goes through at least 2 stages, the active and chronic. During the active stage, the PD may progress or get better. This usually lasts from between 6 and 18 months. While in the active stage, a man should never undergo any form of surgery to correct his condition. I received an email from a very unfortunate reader whose physician operated during the very early stage of his PD.
comments = i had penile plication 6 mths after pd diagnosis,this was an abject failure resulting in loss of feeling and increased curveture and also permanent sutures appear to be all over the place. further consultations with other uroligists suggested the procedure was premature and in any case they would not use this method. i am in the process of taking legal action and am wondering if you are aware of any successful cases.