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NEWS IN BRIEF
One of the great aspects of science is that through intuition or serendipity
someone will find a correlation between two seemingly unrelated facts
which may turn out to have some significance. When men develop PD
they usually experience a decrease in elasticity of the spongy tissue of
their penis and this is one reason why they experience a decrease in
penile length and girth. An Israeli professor of plant physiology who was
interested in the problem of plant plasticity hypothesized that plants and
male erectile dysfunction problems were similar and came up with the idea
of adding an ED drug to flowers to determine if this would keep them fresh
and firm. Yes, these drugs do keep plants fresher as compared to plain
water. The staff at the eDrugstore Science staff decided to test all the ED
drugs and after 7 days Levitra was the clear winner.
Losartan - In a previous edition, I also pointed out that Losartan has
demonstrated antrifibrotic properties as relates to penile recovery after a
RP. I also suggested that men with early stage PD talk to their urologists
about taking this inexpensive, safe medication in the hopes that it would
lessen the progression of PD. Apparently there is a great deal of interest
in the use of Losartan as a systemic anitfibrotic treatment for a variety of
conditions. Click here for a current clinical trial with this medication on a
fibrotic condition.
PD is a fibrotic disorder in which cells can’t regenerate
and are replaced by scar tissue. There are many human
disorders with these characteristics. Hopefully, someone working in
another field may come up with an effective treatment that can help with
our condition. As in many events in science and life, serendipity plays an
important role. Here is one example. A scientist at the Wistar institute in
Philadelphia was study lupus in mice. To distinguish one mouse from the
other, she poked small holes in their ears. She observed that these small
holes kept closing. And there was no scar, the tissue was perfect. She
wondered if there was a mechanism at play that could be used to treat
injuries. The researcher found that these cells did not express a single
gene, P21, and she is now working on how to suppress this gene in order
to generate injuring healing without any scarring. (Scientific American
March 23, 2010.)
FDA Panel Recommends Approval of Drug For Lung Scarring
An FDA panel voted 9-3 in favor of approving, Pirfenidone, which was
developed to treat an incurable and often fatal lung condition known as
idiopathic pulmonary fibrosis. The developing company conducted two
studies to determine if their drug improved a measure of lung function.
One of the two studies did meet the goal. (Wall Street Journal 03/10/10).
Of course, the hope is that some time in the near future it can be
determined if this medication can be used for our condition.
PD is a disease that goes through at least 2 stages, the active
and chronic. During the active stage, the PD may progress or get better.
This usually lasts from between 6 and 18 months. While in the active
stage, a man should never undergo any form of surgery to correct his
condition. I received an email from a very unfortunate reader whose
physician operated during the very early stage of his PD.
comments = i had penile plication 6 mths after pd diagnosis,this was an
abject failure resulting in loss of feeling and increased curveture and also
permanent sutures appear to be all over the place. further consultations
with other uroligists suggested the procedure was premature and in any
case they would not use this method. i am in the process of taking legal
action and am wondering if you are aware of any successful cases.
