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NEWS IN BRIEF III
Potential Treatments
Unfortunately, men with our disease have no organization to
lobby on our behalf. In researching articles for this site, I
frequently come across what I think are promising
approaches to our disease, but they never get beyond my
comments on this site due to lack of advocacy. I publish
these articles as more of a mental exercise than harboring
any expectations that they will be tested for the treatment of
our disease. In reading about the following medications
remember that PD is considered a wound healing disorder
associated with fibrotic changes (scar tissue) usually
resulting in erectile dysfunction. An adequate level of nitric
oxide is critical for wound healing and the vasodilation
required for an erection, So at least in theory, any
substance that will moderate or reverse fibrotic changes or
lead to an adequate supply of nitric oxide should be of
benefit to us.
Nitroglycerine
Queens University in England published an article on the
use of a very low dose nitroglycerine patch to slow and
even halt progression of prostate cancer. Seventeen men
who had prostate cancer treatment, but continued to exhibit
rising PSA levels were treated with a low a dose
nitroglycerine patch. All but one showed a stabilization or
decrease in the rate of cancer progression as measure by
PSA activity. What does nitroglycreine have to do with a PD
treatment? Nitroglycerine is converted to nitric oxide in the
body.
Nitroglycerine is converted into nitric oxide in the body. To
me, a non scientist, this sounds like an inexpensive, safe
approach to attempt to treat PD, especially in its earliest
stages.
Erythropoietin
According to an article in Prostate Cancer Discovery, The
Brady Urological Institute, Winter 2010, erythropoietin, is a
hormone made in the kidney. It has been shown to preserve
nerve function after an injury and preliminary studies show
that it may help to preserve erectile function after a Radical
Prostatectomy. In a separate article, The American Journal
of Pathology, 2003 reported that this substance was related
to wound healing in laboratory rats.
Sildenafil (Viagra)
This is a common erectile dysfunction drug and was tested
on patients with Idiopathic Pulmonary Fibrosis(IPF). IDF is a
fatal fibrotic disorder of the lungs. Testing on 180 patients
did present some positive, secondary outcomes in the areas
of shortness of breath and quality of life. I have written a
number of previous articles about evidence that common
ED drugs exhibit anti-firbrotic properties, particularly during
the early stages of PD and maybe a useful treatment. The
fact that it did help somewhat with another fibrotic disorder
IDF, is an encouraging sign.
Frozen Shoulder (adhesive capsulitis) and what it
maybe able to tell us about what to do and what
to avoid
Frozen shoulder and PD are disorders that
appear to have much in common
Stretching exercises are usually recommended for
patients with a frozen shoulder. They exercises
invariably involve stretching the injured arm towards the
outward, non deformed position.
What does this have to do with our disorder?
Physicians who treat men with PD will recommend that
they remain sexually active. What exactly does this
mean? In contrast to stretching outward towards the
non-deformed position as with a frozen shoulder, during
actual vaginal intercourse, the penis is tensed and via
thrusting significant pressure is applied against the
penis towards the direction of the deformed position.
Particularly during the active phase of the disease this
may result in further injury to the penis. When I first
contracted this disease, I remained sexually active and
engaged in vigorous vaginal intercourse and my
condition worsened considerably. Did this pressure
account for the worsening of my condition? I don’t
really know, but logic and common sense would not
rule out this explanation. Let me know what you think.
Xiaflex Update
I was in the earlier stage of the clinical trial for this drug
and received the placebo resulting in absolutely no
change in my condition. Recently, I was called by the
trial site nurse informing me that further testing will
begin sometime in September 2010. If you are
interested, check the site clinicaltrials.gov for any
announcement.
Potential Treatments
Unfortunately, men with our disease have no organization to
lobby on our behalf. In researching articles for this site, I
frequently come across what I think are promising
approaches to our disease, but they never get beyond my
comments on this site due to lack of advocacy. I publish
these articles as more of a mental exercise than harboring
any expectations that they will be tested for the treatment of
our disease. In reading about the following medications
remember that PD is considered a wound healing disorder
associated with fibrotic changes (scar tissue) usually
resulting in erectile dysfunction. An adequate level of nitric
oxide is critical for wound healing and the vasodilation
required for an erection, So at least in theory, any
substance that will moderate or reverse fibrotic changes or
lead to an adequate supply of nitric oxide should be of
benefit to us.
Nitroglycerine
Queens University in England published an article on the
use of a very low dose nitroglycerine patch to slow and
even halt progression of prostate cancer. Seventeen men
who had prostate cancer treatment, but continued to exhibit
rising PSA levels were treated with a low a dose
nitroglycerine patch. All but one showed a stabilization or
decrease in the rate of cancer progression as measure by
PSA activity. What does nitroglycreine have to do with a PD
treatment? Nitroglycerine is converted to nitric oxide in the
body.
- Increased levels of nitric oxide maybe effective in
preventing progression of PD or reversing its fibrosis
as described Nat Clinical Practice Urology 2006: 3111-5,
37.
- Increased nitric oxide production maybe the reason why
pentoxiflylline has been shown to be somewhat
effective in treating early PD.
Nitroglycerine is converted into nitric oxide in the body. To
me, a non scientist, this sounds like an inexpensive, safe
approach to attempt to treat PD, especially in its earliest
stages.
Erythropoietin
According to an article in Prostate Cancer Discovery, The
Brady Urological Institute, Winter 2010, erythropoietin, is a
hormone made in the kidney. It has been shown to preserve
nerve function after an injury and preliminary studies show
that it may help to preserve erectile function after a Radical
Prostatectomy. In a separate article, The American Journal
of Pathology, 2003 reported that this substance was related
to wound healing in laboratory rats.
Sildenafil (Viagra)
This is a common erectile dysfunction drug and was tested
on patients with Idiopathic Pulmonary Fibrosis(IPF). IDF is a
fatal fibrotic disorder of the lungs. Testing on 180 patients
did present some positive, secondary outcomes in the areas
of shortness of breath and quality of life. I have written a
number of previous articles about evidence that common
ED drugs exhibit anti-firbrotic properties, particularly during
the early stages of PD and maybe a useful treatment. The
fact that it did help somewhat with another fibrotic disorder
IDF, is an encouraging sign.
Frozen Shoulder (adhesive capsulitis) and what it
maybe able to tell us about what to do and what
to avoid
Frozen shoulder and PD are disorders that
appear to have much in common
- Both are connective tissue disorders resulting from
an injury, leading to inflammation, scarring and
tissue shrinkage. In the case of frozen shoulder, it
results in shrinkage of the capsule that surrounds
the normal shoulder joint
- Both occur more frequently in men with diabetes
- It is believed that both have an autoimmune
component
- Xiaflex is being tested as a PD treatment and it is
being considered for testing on frozen shoulder
Stretching exercises are usually recommended for
patients with a frozen shoulder. They exercises
invariably involve stretching the injured arm towards the
outward, non deformed position.
What does this have to do with our disorder?
Physicians who treat men with PD will recommend that
they remain sexually active. What exactly does this
mean? In contrast to stretching outward towards the
non-deformed position as with a frozen shoulder, during
actual vaginal intercourse, the penis is tensed and via
thrusting significant pressure is applied against the
penis towards the direction of the deformed position.
Particularly during the active phase of the disease this
may result in further injury to the penis. When I first
contracted this disease, I remained sexually active and
engaged in vigorous vaginal intercourse and my
condition worsened considerably. Did this pressure
account for the worsening of my condition? I don’t
really know, but logic and common sense would not
rule out this explanation. Let me know what you think.
Xiaflex Update
I was in the earlier stage of the clinical trial for this drug
and received the placebo resulting in absolutely no
change in my condition. Recently, I was called by the
trial site nurse informing me that further testing will
begin sometime in September 2010. If you are
interested, check the site clinicaltrials.gov for any
announcement.
