A research paper appeared in the International Journal of
Hyperthermia, June 2005, which strongly suggests that
hyperthermia is a safe, inexpensive and effective treatment
for advanced PD.  If am reading the study correctly, the
treatment group even included those men with calcification
present.  The presence of calcification is universally used as
an exclusion factor when testing any conservative treatment.  
I did a Pubmed and Google search and was unable to find any
follow-up material on this study.

Study rationale – previous experience with hyperthermia in
the treatment of plaque and fibrosis in the field of orthopedics
led the authors to explore the possibility of using the same
mode of treatment for advanced PD.  According to the
authors, hyperthermia dilates the micro vessels resulting in
increased blood flow to the area by generating heat which
also encourages cell and tissue repair.  

Study method – 60 patients were enrolled in the study with a
mean post 13 months diagnosis of PD.  The treatment group
received heat therapy, lasting 20 minutes, twice a week for 5
weeks. A 2nd cycle was repeated after a 1 month interval for a
total of 10 treatments.  Care was taken to insure that the heat
therapy was between 39-40 degrees Celsius, the same
temperature used in orthopedic treatments.  The control
group received a single 10mg intralesional injection of
Verapamil once a week for 3 months.  It was reported that
there was significant relief of both subjective and objective
symptoms.  The treatment group did not show any adverse
side effects.  
The results are impressive, but frankly I am  
skeptical.  Here is a study with exceptional results reported,
no adverse side affects, not very expensive and no one has
tried to duplicate it.  Something is just not right.      


We now have a physician in Brazil who is conducting a clinical
trial where the placebo is heat treatment and the treatment
group is receiving a combination of heat, Vitamin D and
testosterone injections.  Each group will be treated with an
infrared lamp of 150w at a distance of approx 20cm from the
plaque and curvature.  In addition, the treatment group will
receive 4000 units of Vitamin D daily and one injection of
testosterone every 2 weeks if the patient has testosterone
levels under the normal level.  It is anticipated that this
experiment will end March 2010.  I originally thought this
experiment was to test the effectiveness of heat on PD, but it
appears to be a follow up to a study which suggests that low
testosterone levels may be a causative factor in the
development of PD and that the lower the level of
testosterone, the greater the penile curvature. (International
Society of Sexual Medicine 2009.)

In the testosterone study, medical records of 121 consecutive
patients were reviewed over a 2 year period and it was
demonstrated that there was a significant positive correlation
between low testosterone and the development of PD and
degree of curvature.
The researchers are now taking these
findings a step further and from my reading of the study,
hope to demonstrate that testosterone, Vitamin D and heat
reverse PD.  Let's hope they have success.