Much of the literature states that PD is a disease that primarily affects men of Northern European background. That is why it is surprising that so much good research is coming out of Iran. I can't explain why this is happening, but all I can say is thank you and keep up the good work. Previously, I published an article documenting research in Iran which raises serious questions about the accepted hypothesis that PD results from penile trauma. If you want to read this article, type the words "penile trauma" in the search block of this page.
I have found 2 other articles recently published based on Iranian research that are worth reading.
Omega-3 As A Treatment For Early Stage PD
A total of 224 patients with early chronic stage PD, aged 38-59 years of age were randomized into 2 groups, placebo and receipt of omega-3 fatty acids for a period 6 months. No significant improvements were observed with regard to PD, pain or ED. These data fail to support a beneficial effect of omega-3 in early-chronic stage PD.
Pentoxifylline As An Effective Treatment
In creating this website I have to make certain assumptions about its readership. One is that it is likely that my readers surf the net on a regular basis to find articles about PD and are fairly knowledgeable about the latest developments. I assume most readers have seen news of this pentoxifylline research, but for those of you who have not, this is an important finding. An Iranian medical facility has performed the first large, randomized, placebo controlled clinical trial to examine the safety and efficacy of pentoxifylline on early chronic pd.
It is a vasodilator that changes the shape of red blood cells in your blood which makes its easier to fit into small arteries. Usually prescribed for peripheral artery disease
it has demonstrated anti inflammatory and anti fibrotic properties
Used in treatmenting human fibrotic conditions such as radiation induced fibrosis and alcoholic hepatitis
Generally well tolerated with the most common side effects being mild headaches and nausea
For this study, researchers identified 3 stages of PD, the acute or inflammatory stage usually lasting 6-18 months, followed by an early chronic stage and finally a staple phase. Two hundred fifty eight men from a patient population at a sexual dysfunction clinic made up the clinical trial population. Those treated with pentoxiflylline received 400 mg 2x daily for a period of 6 months. The treated group showed a modest, but statistically significant improvement in outcomes as compared to the placebo group.
If you are a man who has been recently diagnosed with PD or have had PD for what can be classified as the early chronic phase, run, don't walk to your urologist and ask to be prescribed pentoxifylline. It has been shown to be moderately effective in treating symptoms and preventing disease progression. Note that according to the researchers , "There was a significant negative correlation between disease duration and a positive response to pentoxifylline."