Good Research Coming Out of Iran

Much of the literature states that PD is a disease that primarily
affects men of Northern European background. That is why it is
surprising that so much good research is coming out of Iran.  I can't
explain why this is happening, but all I can say is thank you and
keep up the good work.  Previously, I published an article
documenting research in Iran which raises serious questions about
the accepted hypothesis that PD results from penile trauma. If you
want to read this article, type the words "penile trauma" in the
search block of this page.

I have found 2 other articles recently published based on Iranian
research that are worth reading.  

Omega-3 As A Treatment For Early Stage PD

A total of 224 patients with early chronic stage PD, aged 38-59
years of age were randomized into 2 groups, placebo and receipt of
omega-3 fatty acids for a period 6 months. No significant
improvements were observed with regard to PD, pain or ED.  
These data fail to support a beneficial effect of omega-3 in
early-chronic stage PD.

Pentoxifylline As An Effective Treatment

In creating this website I have to make certain assumptions about
its readership.  One is that it is likely that my readers surf the net
on a regular basis to find articles about PD and are fairly
knowledgeable about the latest developments.  I assume most
readers have seen news of this pentoxifylline research, but for
those of you who have not, this is an important finding.  An Iranian
medical facility has performed the first large, randomized, placebo
controlled clinical trial to examine the safety and efficacy of
pentoxifylline on early chronic pd.

  • It is a vasodilator that changes the shape of red blood cells in your blood
    which makes its easier to fit into small arteries.  Usually prescribed for
    peripheral artery disease
  • it has demonstrated anti inflammatory and anti fibrotic properties
  • Used in treatmenting human fibrotic conditions such as radiation
    induced fibrosis and alcoholic hepatitis
  • Generally well tolerated with the most common side effects being mild
    headaches  and nausea

For this study, researchers identified 3 stages of PD, the acute or
inflammatory stage usually lasting 6-18 months, followed by an
early chronic stage and finally a staple phase.  Two hundred fifty
eight men from a patient population at a sexual dysfunction clinic
made up the clinical trial population. Those treated with
pentoxiflylline received 400 mg 2x daily for a period of 6 months.
The treated group showed a modest, but statistically significant
improvement in outcomes as compared to the placebo group.

If you are a man who has been recently diagnosed with PD or
have had PD for what can be classified as the early chronic
phase, run, don't walk to your urologist and ask to be
prescribed pentoxifylline. It has been shown to be moderately
effective in treating symptoms and preventing disease
progression. Note that according to the researchers , "There
was a significant negative correlation between disease
duration and a positive response to pentoxifylline."