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MORE EVIDENCE FROM THE FEMALE GENITALIA
The same medical facility in Turkey that conducted the
previously mentioned research did another innovative and
important medical study on the effect of sildenafil citrate on
the genital organs in female rats. (Asia Journal of Andrology,
2003 March). The research focused primarily, but not
exclusively, on the corpus CC. Note that the CC is
ensheathed by a thick fibrous tissue structure; a TA
Twenty female rates were divided into two groups; one was
the control and the other received sildenafil citrate 3 days a
week for 4 weeks. The dose was less than that for humans
on a per kg body weight basis. After treatment the rats were
sacrificed and their tissue was examined.
In Exhibit 1 there are tissue samples from the corpus
cavernosum (control group). The organized fibers are
arranged in sheets that can slide past each other during
penile expansion and contraction. In Exhibit 2 note the
abnormal densely packed collagen in the treated group
which prevents normal penile expansion and contraction.
This is similar to the collagen disturbance found in PD
plaque. View collagen in PD plaque.
previously mentioned research did another innovative and
important medical study on the effect of sildenafil citrate on
the genital organs in female rats. (Asia Journal of Andrology,
2003 March). The research focused primarily, but not
exclusively, on the corpus CC. Note that the CC is
ensheathed by a thick fibrous tissue structure; a TA
Twenty female rates were divided into two groups; one was
the control and the other received sildenafil citrate 3 days a
week for 4 weeks. The dose was less than that for humans
on a per kg body weight basis. After treatment the rats were
sacrificed and their tissue was examined.
- Both vaginal and clitoral tissue specimens in the treated
group showed increased connective tissue fibers and
shortened immature collagen with striation.
- Fibroblasts (scar cells) in the treated group were active.
- According to the authors, an increase in connective
tissue and dense collagen fibers in the CC was
demonstrated. Fibroblastic (scar tissue) activation
could be irreversible, so prolonged use of sildenafil
citrate may result in fibrotic changes in both clitoral and
penile tissues.
In Exhibit 1 there are tissue samples from the corpus
cavernosum (control group). The organized fibers are
arranged in sheets that can slide past each other during
penile expansion and contraction. In Exhibit 2 note the
abnormal densely packed collagen in the treated group
which prevents normal penile expansion and contraction.
This is similar to the collagen disturbance found in PD
plaque. View collagen in PD plaque.
Discussion: From this research what seems irefutable is that
the prolonged use of ED drugs result in fibrotic changes of the
CC for both the male and female. As of yet we don't know if this
process also affects the TA. There are a number of sites where
the public and health professionals can report adverse
reactions to drugs. I checked them and did not see much in the
way of PD reported by men using ED drugs. Could this be due
to embarrassment? Or, have men used these drugs for a
number and years and finally developed PD. As a result of the
time lag, not making the connection. We really don't know.
In the News In Brief II section pay particular attention to the
article from Brazil. They have found that the scarring process
travels from the TA to the CC. This important research would
make it more reasonable to assume that the effects of injury
would migrate within the penile tissue, e.g., from the CC to the
TA resulting in PD.