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IS THIS OVER THE COUNTER MEDICATION
AN EFFECTIVE TREATMENT FOR EARLY
CHRONIC PEYRONIES DISEASE?
ORIGINAL RESEARCH
INTERNATIONAL JOURNAL
OF IMPOTENCE RESEARCH
No oral medication has been proven to be an
effective treatment for Peyronies Disease (PD).
From June 2006 to May 2009, a urologist in private
practice in Tehran, Iran conducted the only
prospective, placebo-controlled, randomized
clinical trial to test the effectiveness of
CoenzymeQ10 (CoQ10) in patients with PD.
CoQ10 is a vitamin like substance whose primary
functions are as a cellular energy carrier and
antioxidant. Organs with the highest energy
requirements, heart, liver and kidney, have the
highest CoQ10 concentrations. It is found in
almost every cell in the body.
What follows is rather complex and detailed. In
order to understand the findings, please read
carefully.
The study physician defined PD as having 3
distinct stages:
1. Acute - Initial inflammatory reaction
2. Early Chronic - Pain during erection, penile
curvature not affecting vaginal penetration,
palpable plaque without pain or calcification
3. Chronic - Pain resolution and formation of
fibrous, inelastic scar tissue
All study participants were in the early chronic
phase of the disease and met the following criteria:
Patients were then categorized into 3 groups:
All eligible participants were given a blind placebo
for 1 week. Anyone who reported an improvement
was dropped from the study.
INTERNATIONAL JOURNAL
OF IMPOTENCE RESEARCH
No oral medication has been proven to be an
effective treatment for Peyronies Disease (PD).
From June 2006 to May 2009, a urologist in private
practice in Tehran, Iran conducted the only
prospective, placebo-controlled, randomized
clinical trial to test the effectiveness of
CoenzymeQ10 (CoQ10) in patients with PD.
CoQ10 is a vitamin like substance whose primary
functions are as a cellular energy carrier and
antioxidant. Organs with the highest energy
requirements, heart, liver and kidney, have the
highest CoQ10 concentrations. It is found in
almost every cell in the body.
What follows is rather complex and detailed. In
order to understand the findings, please read
carefully.
The study physician defined PD as having 3
distinct stages:
1. Acute - Initial inflammatory reaction
2. Early Chronic - Pain during erection, penile
curvature not affecting vaginal penetration,
palpable plaque without pain or calcification
3. Chronic - Pain resolution and formation of
fibrous, inelastic scar tissue
All study participants were in the early chronic
phase of the disease and met the following criteria:
- Disease duration was +12 months
- Patients were between 18 and 60 years of age
- Erectile Dysfunction without any obvious organic cause
- Presence of plaque
- Presence of pain
- Penile curvature
Patients were then categorized into 3 groups:
- Class 1 - Plaque less than 1 cm and curvature less than 30
degrees - Class II - Plaque between 1-2 cm and curvature between
30-60 degrees - Class III - Plaque greater than 2 cm and curvature 60+
degrees
All eligible participants were given a blind placebo
for 1 week. Anyone who reported an improvement
was dropped from the study.
Never Ending
Controversy-
Use of Verapamil
Injections
Controversy-
Use of Verapamil
Injections
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